Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Long-term exposure to a diabetic environment leads to changes in bone metabolism and
impaired bone micro-architecture through a variety of mechanisms on molecular and …

In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …

Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …

The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

For years many have believed that genetic heritage defined one's destiny, if an individual
would grow to be healthy, or if he or she would suffer from chronic illness or cancer. Recent …

It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …

Epigenetic patterns, such as DNA methylation, histone modifications, and non-coding RNAs,
can be both driver factors and characteristic features of certain malignancies. Aberrant DNA …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

The direct/indirect responsibility of the gut microbiome in disease induction in and outside
the digestive tract is well studied. These results are usually from the overpopulation of …