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CAR-based therapies: opportunities for immuno-medicine beyond cancer
One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …
are engineered to recognize and destroy cancerous cells. Patients with previously …
Current best practice in hepatitis B management and understanding long-term prospects for cure
The hepatitis B virus (HBV) is a major cause of cirrhosis and hepatocellular carcinoma
worldwide. Despite an effective vaccine, the prevalence of chronic infection remains high …
worldwide. Despite an effective vaccine, the prevalence of chronic infection remains high …
Fine-tuning through generations: advances in structure and production of CAR-T therapy
Z Zheng, S Li, M Liu, C Chen, L Zhang, D Zhou - Cancers, 2023 - mdpi.com
Simple Summary Chimeric antigen receptor (CAR)-T cell therapy has been highly
successful in treating hematological malignancies like leukemia and lymphoma, leading to …
successful in treating hematological malignancies like leukemia and lymphoma, leading to …
Application of CAR-T cell therapy beyond oncology: autoimmune diseases and viral infections
Adoptive cell transfer (ACT) has long been at the forefront of the battle with cancer that
began last century with the therapeutic application of tumor-infiltrating lymphocytes (TILs) …
began last century with the therapeutic application of tumor-infiltrating lymphocytes (TILs) …
CAR T cells beyond cancer: hope for immunomodulatory therapy of infectious diseases
M Seif, H Einsele, J Löffler - Frontiers in immunology, 2019 - frontiersin.org
Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite
the progress in drug development, the occurrence of microbial resistance is still a significant …
the progress in drug development, the occurrence of microbial resistance is still a significant …
Advances in targeting the innate and adaptive immune systems to cure chronic hepatitis B virus infection
Z Meng, Y Chen, M Lu - Frontiers in Immunology, 2020 - frontiersin.org
“Functional cure” is being pursued as the ultimate endpoint of antiviral treatment in chronic
hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …
hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …
[HTML][HTML] Immunotherapy for advanced hepatocellular carcinoma, where are we?
A couple of molecular-targeting medications, such as Lenvatinib, are available for the
treatment of hepatocellular carcinoma (HCC) in addition to Sorafenib in an advanced stage …
treatment of hepatocellular carcinoma (HCC) in addition to Sorafenib in an advanced stage …
[HTML][HTML] New approaches to the treatment of chronic hepatitis B
The currently recommended treatment for chronic hepatitis B virus (HBV) infection achieves
only viral suppression whilst on therapy, but rarely hepatitis B surface antigen (HBsAg) loss …
only viral suppression whilst on therapy, but rarely hepatitis B surface antigen (HBsAg) loss …
CAR Immunotherapy for the treatment of infectious diseases: a systematic review
E Morte-Romea, C Pesini… - Frontiers in …, 2024 - frontiersin.org
Immunotherapy treatments aim to modulate the host's immune response to either mitigate it
in inflammatory/autoimmune disease or enhance it against infection or cancer. Among …
in inflammatory/autoimmune disease or enhance it against infection or cancer. Among …
[HTML][HTML] Alternative CAR therapies: recent approaches in engineering chimeric antigen receptor immune cells to combat cancer
For nearly three decades, chimeric antigen receptors (CARs) have captivated the interest of
researchers seeking to find novel immunotherapies to treat cancer. CARs were first …
researchers seeking to find novel immunotherapies to treat cancer. CARs were first …