CAR-based therapies: opportunities for immuno-medicine beyond cancer

H Aghajanian, JG Rurik, JA Epstein - Nature metabolism, 2022 - nature.com
One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …

Current best practice in hepatitis B management and understanding long-term prospects for cure

D Yardeni, KM Chang, MG Ghany - Gastroenterology, 2023 - Elsevier
The hepatitis B virus (HBV) is a major cause of cirrhosis and hepatocellular carcinoma
worldwide. Despite an effective vaccine, the prevalence of chronic infection remains high …

Fine-tuning through generations: advances in structure and production of CAR-T therapy

Z Zheng, S Li, M Liu, C Chen, L Zhang, D Zhou - Cancers, 2023 - mdpi.com
Simple Summary Chimeric antigen receptor (CAR)-T cell therapy has been highly
successful in treating hematological malignancies like leukemia and lymphoma, leading to …

Application of CAR-T cell therapy beyond oncology: autoimmune diseases and viral infections

E Zmievskaya, A Valiullina, I Ganeeva, A Petukhov… - Biomedicines, 2021 - mdpi.com
Adoptive cell transfer (ACT) has long been at the forefront of the battle with cancer that
began last century with the therapeutic application of tumor-infiltrating lymphocytes (TILs) …

CAR T cells beyond cancer: hope for immunomodulatory therapy of infectious diseases

M Seif, H Einsele, J Löffler - Frontiers in immunology, 2019 - frontiersin.org
Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite
the progress in drug development, the occurrence of microbial resistance is still a significant …

Advances in targeting the innate and adaptive immune systems to cure chronic hepatitis B virus infection

Z Meng, Y Chen, M Lu - Frontiers in Immunology, 2020 - frontiersin.org
“Functional cure” is being pursued as the ultimate endpoint of antiviral treatment in chronic
hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …

[HTML][HTML] Immunotherapy for advanced hepatocellular carcinoma, where are we?

L Zhang, J Ding, HY Li, ZH Wang, J Wu - Biochimica et Biophysica Acta …, 2020 - Elsevier
A couple of molecular-targeting medications, such as Lenvatinib, are available for the
treatment of hepatocellular carcinoma (HCC) in addition to Sorafenib in an advanced stage …

[HTML][HTML] New approaches to the treatment of chronic hepatitis B

A Alexopoulou, L Vasilieva, P Karayiannis - Journal of Clinical Medicine, 2020 - mdpi.com
The currently recommended treatment for chronic hepatitis B virus (HBV) infection achieves
only viral suppression whilst on therapy, but rarely hepatitis B surface antigen (HBsAg) loss …

CAR Immunotherapy for the treatment of infectious diseases: a systematic review

E Morte-Romea, C Pesini… - Frontiers in …, 2024 - frontiersin.org
Immunotherapy treatments aim to modulate the host's immune response to either mitigate it
in inflammatory/autoimmune disease or enhance it against infection or cancer. Among …

[HTML][HTML] Alternative CAR therapies: recent approaches in engineering chimeric antigen receptor immune cells to combat cancer

C Moreno, C Haynie, A Cheever, KS Weber - Biomedicines, 2022 - mdpi.com
For nearly three decades, chimeric antigen receptors (CARs) have captivated the interest of
researchers seeking to find novel immunotherapies to treat cancer. CARs were first …