The Wingless (Wnt)/β-catenin pathway has long been associated with tumorigenesis, tumor
plasticity, and tumor-initiating cells called cancer stem cells (CSCs). Wnt signaling has …

Gynecologic malignancies, including ovarian cancer, endometrial cancer, and cervical
cancer, affect hundreds of thousands of women worldwide every year. Wnt signaling …

Cell signaling pathways are the mechanisms by which cells transduce external stimuli,
which control the transcription of genes, to regulate diverse biological effects. In cancer …

Cervical cancer is among the most commonly diagnosed cancer in women, supporting the
need for identification of novel prognostic and predictive biomarkers to predict the risk of …

Epithelial carcinomas are well known to activate a prolonged wound-healing program that
promotes malignant transformation. Wound closure requires the activation of keratinocyte …

Cervical cancer (CC) is the second most common malignant cancer in women. CC is difficult
to diagnose, has a high recurrence rate, and is resistant to systemic therapies; as a result …

Human Wnt family comprises 19 proteins which are critical to embryo development and
tissue homeostasis. Binding to different frizzled (FZD) receptor, Wnt7a initiates both β …

Due to the therapy resistance and frequent metastasis, pancreatic ductal adenocarcinoma
(PDAC) remains one of the most malignant carcinoma. WNT7A, an important ligand of Wnt/β …

Lgr5+ supporting cells (SCs) are enriched hair cell (HC) progenitors in the cochlea. Both in
vitro and in vivo studies have shown that HC injury can spontaneously activate Lgr5+ …

Background The E6 oncoproteins of human papillomavirus (HPV) 16/18 are the critical
drivers of cervical cancer (CC) progression. Extracellular vesicles (EVs) are emerging as …