[HTML][HTML] The resurrection of digital triplet: A cognitive pillar of human-machine integration at the dawn of industry 5.0

H Alimam, G Mazzuto, N Tozzi, FE Ciarapica… - Journal of King Saud …, 2023‏ - Elsevier
The integration of AI technology with digital transformation has profoundly shaped the
evolution towards digital triplet architecture, grounded in human-centric methodologies. By …

A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling

F Destro, M Barolo - International journal of pharmaceutics, 2022‏ - Elsevier
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

Leveraging the potential of fourth industrial revolution technologies to reduce and valorise waste and by-products in the dairy sector

A Hassoun, I Tarchi, A Aït-Kaddour - Current Opinion in Green and …, 2024‏ - Elsevier
Recent years have seen a growing convergence between digital, physical, and biological
disciplines, heralding a major shift in agriculture and the food industry, led by advanced …

A roadmap for model-based bioprocess development

K Mu'azzam, FVS da Silva, J Murtagh… - Biotechnology …, 2024‏ - Elsevier
The bioprocessing industry is undergoing a significant transformation in its approach to
quality assurance, shifting from the traditional Quality by Testing (QbT) to Quality by Design …

Digital models in biotechnology: Towards multi-scale integration and implementation

FSF Hartmann, IA Udugama, GM Seibold… - Biotechnology …, 2022‏ - Elsevier
Industrial biotechnology encompasses a large area of multi-scale and multi-disciplinary
research activities. With the recent megatrend of digitalization swee** across all …

[HTML][HTML] Computational methods for biofabrication in tissue engineering and regenerative medicine-a literature review

R Bardini, S Di Carlo - Computational and Structural Biotechnology Journal, 2024‏ - Elsevier
This literature review rigorously examines the growing scientific interest in computational
methods for Tissue Engineering and Regenerative Medicine biofabrication, a leading-edge …

[HTML][HTML] Digital twin application for model-based doe to rapidly identify ideal process conditions for space-time yield optimization

B Bayer, R Dalmau Diaz, M Melcher, G Striedner… - Processes, 2021‏ - mdpi.com
The fast exploration of a design space and identification of the best process conditions
facilitating the highest space-time yield are of great interest for manufacturers. To obtain this …

[HTML][HTML] Economic, technical, and environmental evaluation of retrofitting scenarios in a full-scale industrial wastewater treatment system

V Monje, M Owsianiak, H Junicke, K Kjellberg… - Water Research, 2022‏ - Elsevier
The use of mathematical models is a well-established procedure in the field of (waste) water
engineering to “virtually” evaluate the feasibility of novel process modifications. In this way …

Digital twins for continuous mRNA production

H Helgers, A Hengelbrock, A Schmidt, J Strube - Processes, 2021‏ - mdpi.com
The global coronavirus pandemic continues to restrict public life worldwide. An effective
means of limiting the pandemic is vaccination. Messenger ribonucleic acid (mRNA) vaccines …

Towards digitalization in bio-manufacturing operations: a survey on application of big data and digital twin concepts in Denmark

I A. Udugama, M Öner, PC Lopez… - Frontiers in Chemical …, 2021‏ - frontiersin.org
Digitalization in the form of Big Data and Digital Twin inspired applications are hot topics in
today's bio-manufacturing organizations. As a result, many organizations are diverting …