Phototoxicity frequently occurs during live fluorescence microscopy, and its consequences
are often underestimated. Damage to cellular macromolecules upon excitation light …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Proper preimplantation development is essential to assemble a blastocyst capable of
implantation. Live imaging has uncovered major events driving early development in mouse …

During embryogenesis, tissues and organs are progressively shaped into their functional
morphologies. While the information about tissue and organ shape is encoded genetically …

The sculpting of embryonic tissues and organs into their functional morphologies involves
the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in …

During embryonic development, a simple ball of cells re-shapes itself into the elaborate
body plan of an animal. This requires dramatic cell shape changes and cell movements …

Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells
to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on …

Cell-extracellular matrix interactions have been studied extensively using cells cultured in
vitro. These studies indicate that focal adhesion (FA)-based cell-extracellular matrix …

Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to
their mechanical environment through mechanosensitive pathways. How mechanical cues …

Circular or ring-like actin structures play important roles in various developmental and
physiological processes. Commonly, these rings are composed of actin filaments and …