The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Several non-redundant features of the tumour microenvironment facilitate
immunosuppression and limit anticancer immune responses. These include physical …

Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that essentially
support germinal center responses where high-affinity and long-lived humoral immunity is …

The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic,
whereas the microenvironment of tissues affected by chronic inflammatory disease is pro …

Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …

T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor
immunity, but the mechanisms governing their cellular redox homeostasis remain elusive …

Background & Aims Regulatory T-cells (Tregs) impair cancer immunosurveillance by
creating an immunosuppressive environment that fosters tumor cell survival. Our previous …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …