The genomic landscape of cutaneous melanoma
Somatic mutation analysis of melanoma has been performed at the single gene level
extensively over the past several decades. This has provided considerable insight into the …
extensively over the past several decades. This has provided considerable insight into the …
Roles of the CCR4‐Not complex in translation and dynamics of co‐translation events
MA Collart, L Audebert… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Abstract The Ccr4‐Not complex is a global regulator of mRNA metabolism in eukaryotic cells
that is most well‐known to repress gene expression. Delivery of the complex to mRNAs …
that is most well‐known to repress gene expression. Delivery of the complex to mRNAs …
Comparative genomics provides etiologic and biological insight into melanoma subtypes
Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …
Chemoradiation increases PD-L1 expression in certain melanoma and glioblastoma cells
Immunotherapy approaches currently make their way into the clinics to improve the outcome
of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) …
of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) …
Neoantigen targeting—dawn of a new era in cancer immunotherapy?
TC Wirth, F Kühnel - Frontiers in immunology, 2017 - frontiersin.org
During their development and progression tumors acquire numerous mutations that, when
translated into proteins give rise to neoantigens that can be recognized by T cells. Initially …
translated into proteins give rise to neoantigens that can be recognized by T cells. Initially …
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma
The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a
poor prognosis and is of unknown pathogenesis. We performed exome sequencing of …
poor prognosis and is of unknown pathogenesis. We performed exome sequencing of …
The promise of multi-omics and clinical data integration to identify and target personalized healthcare approaches in autism spectrum disorders
Complex diseases are caused by a combination of genetic and environmental factors,
creating a difficult challenge for diagnosis and defining subtypes. This review article …
creating a difficult challenge for diagnosis and defining subtypes. This review article …
Non-BRAF mutant melanoma: molecular features and therapeutical implications
I Vanni, ET Tanda, B Dalmasso, L Pastorino… - Frontiers in Molecular …, 2020 - frontiersin.org
Melanoma is one of the most aggressive tumors of the skin, and its incidence is growing
worldwide. Historically considered a drug resistant disease, since 2011 the therapeutic …
worldwide. Historically considered a drug resistant disease, since 2011 the therapeutic …
Targeting regulatory T cells for immunotherapy in melanoma
Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a
key to immune suppressive microenvironment in solid tumors. Many studies have revealed …
key to immune suppressive microenvironment in solid tumors. Many studies have revealed …
Spliced peptides and cytokine-driven changes in the immunopeptidome of melanoma
Antigen recognition by CD8+ T cells is governed by the pool of peptide antigens presented
on the cell surface in the context of HLA class I complexes. Studies have shown not only a …
on the cell surface in the context of HLA class I complexes. Studies have shown not only a …