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Incorporating ecology into gene drive modelling
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …
wild populations, represents a promising new tool in the fight against vector‐borne diseases …
Amaranthus palmeri S. Watson reproduction system: Implications for distribution and management strategies
Amaranthus palmeri S. Watson is one of the most troublesome weed species worldwide,
and is considered one of the most devastating weeds in agricultural fields in the United …
and is considered one of the most devastating weeds in agricultural fields in the United …
Leveraging a natural murine meiotic drive to suppress invasive populations
Invasive rodents are a major cause of environmental damage and biodiversity loss,
particularly on islands. Unlike insects, genetic biocontrol strategies including population …
particularly on islands. Unlike insects, genetic biocontrol strategies including population …
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
Improving the suppressive power of homing gene drive by co-targeting a distant-site female fertility gene
Gene drive technology has the potential to address major biological challenges. Well-
studied homing suppression drives have been shown to be highly efficient in Anopheles …
studied homing suppression drives have been shown to be highly efficient in Anopheles …
Gene drives for vertebrate pest control: Realistic spatial modelling of eradication probabilities and times for island mouse populations
Invasive alien species continue to threaten global biodiversity. CRISPR‐based gene drives,
which can theoretically spread through populations despite imparting a fitness cost, could be …
which can theoretically spread through populations despite imparting a fitness cost, could be …
Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models
Suppression gene drives bias their inheritance to spread through a population, potentially
eliminating it when they reach high frequency. CRISPR homing suppression drives have …
eliminating it when they reach high frequency. CRISPR homing suppression drives have …
Modelling homing suppression gene drive in haplodiploid organisms
Y Liu, J Champer - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
Gene drives have shown great promise for suppression of pest populations. These
engineered alleles can function by a variety of mechanisms, but the most common is the …
engineered alleles can function by a variety of mechanisms, but the most common is the …
Stochastic models of Mendelian and reverse transcriptional inheritance in state-structured cancer populations
Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key
role in the adaptation of cancer cells to stressful environments and in promoting therapeutic …
role in the adaptation of cancer cells to stressful environments and in promoting therapeutic …
Simulations reveal high efficiency and confinement of a population suppression CRISPR toxin-antidote gene drive
Y Zhu, J Champer - ACS Synthetic Biology, 2023 - ACS Publications
Though engineered gene drives hold great promise for spreading through and suppressing
populations of disease vectors or invasive species, complications such as resistance alleles …
populations of disease vectors or invasive species, complications such as resistance alleles …