Emerging models of the bacterial nucleoid show that nucleoid-associated proteins (NAPs)
and transcription contribute in combination to the dynamic nature of nucleoid structure …

If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in
order to activate transcription in response to growth signals or environmental cues …

Translation, the decoding of mRNA into protein, is the third and final element of the central
dogma. The ribosome, a nucleoprotein particle, is responsible and essential for this process …

A fundamental principle of exponential bacterial growth is that no more ribosomes are
produced than are necessary to support the balance between nutrient availability and …

Decades of research have probed the interplay between chromatin (genomic DNA
associated with proteins and RNAs) and transcription by RNA polymerase (RNAP) in all …

The genetic bases of adaptation are being investigated in 12 populations of Escherichia coli,
founded from a common ancestor and serially propagated for 20,000 generations, during …

Recent studies have revealed that the bacterial nucleoid is a dynamic entity that alters its
overall structure in response to changes in both growth rate and growth phase. These …

The immutability of the genetic code has been challenged with the successful reassignment
of the UAG stop codon to non-natural amino acids in Escherichia coli. In the present study …

Over the recent decade, the central importance of DNA supercoiling in chromosome
organization and global gene regulation of bacteria became more and more visible. With a …