Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular
functions throughout all phases of the cell cycle. Altered tubulin isotype composition of …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

The β‐tubulins are microtubule components encoded by a multigene family, which produces
slightly different proteins with complex expression patterns. Several widely used anticancer …

Microtubules are essential cellular polymers assembled from tubulin heterodimers. The
tubulin dimer consists of a compact folded globular core and intrinsically disordered C …

Microtubules are hollow, cylindrical polymers of the protein α, β tubulin, that interact
mechanochemically with a variety of macromolecules. Due to their mechanically robust …

Proteins with knotted configurations, in comparison with unknotted proteins, are restricted in
conformational space. Little is known regarding whether knotted proteins have sufficient …

Microtubules (MTs) are important cytoskeletal polymers engaged in a number of specific
cellular activities including the traffic of organelles using motor proteins, cellular architecture …

The antitumor macrolide aplyronine A (ApA) disturbs microtubule (MT) dynamics by inducing
the protein–protein interaction (PPI) between actin and tubulin. However, the detailed …

Tubulin, the most abundant axonemal protein, is extensively modified by several highly
conserved post-translational mechanisms including acetylation, detyrosination …

Tubulin heterodimers are the building blocks of microtubules and disruption of their
dynamics is exploited in the treatment of cancer. Electric fields at certain frequencies and …