Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect
over 500 million people by 2030. However, this growing burden of disease has not been met …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …

The treatment of diabetes mellitus represents one of the greatest medical challenges of our
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells …

MicroRNAs (miRNAs) are evolutionarily conserved, small noncoding RNAs that are believed
to play fundamental roles in various biological processes through regulation of gene …

As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …