Suppression of the immune system has been constantly reported in the last years as a
classical side effect of opioid drugs. Most of the studies on the immunological properties of …

Preclinical and clinical studies have sought to better understand the effect of anesthetic
agents, both volatile and intravenous, and perioperative adjuvant medications on immune …

Opioids are the prototypical analgesics, antitussives, and antidiarrheal drug class. The
opioid receptor system or opioid effects have been identified in numerous animal species …

Introduction: Perioperative anesthesia and analgesia exacerbate immunosuppression in
immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti …

Accumulated basic and clinical data suggest that total intravenous anesthesia with propofol,
cyclooxygenase antagonists, and regional anesthesia can decrease negative …

Opioids are respiratory depressants and heroin/opioid overdose is a major contributor to the
excess mortality of heroin addicts. The individual and situational variability of respiratory …

Background: Clusters of differentiation 39 and 73, enzymes expressed on the surface of
regulatory T cells, promote cancer recurrence and metastasis by suppressing immune cells …

Although there is a biologically plausible story, evidence for the action of opioids on cancer
is mixed. Indeed, it may even be that in the chronic setting morphine has a beneficial effect …

Background During general anesthesia, the surgical pleth index (SPI) monitors nociception.
The evidence of SPI in the elderly remains scarce. We aimed to investigate whether there is …

Résumé Objectif L'action inhibitrice de la ketamine sur le recepteur du N-methyle-D-
aspartate et ses effets anti-inflammatoires pourraient procurer une immunomodulation …