Reconstructing computational system dynamics from neural data with recurrent neural networks

D Durstewitz, G Koppe, MI Thurm - Nature Reviews Neuroscience, 2023 - nature.com
Computational models in neuroscience usually take the form of systems of differential
equations. The behaviour of such systems is the subject of dynamical systems theory …

[HTML][HTML] The quest for multiscale brain modeling

E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

Spontaneous behaviors drive multidimensional, brainwide activity

C Stringer, M Pachitariu, N Steinmetz, CB Reddy… - Science, 2019 - science.org
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

Integrated information theory: from consciousness to its physical substrate

G Tononi, M Boly, M Massimini, C Koch - Nature reviews neuroscience, 2016 - nature.com
In this Opinion article, we discuss how integrated information theory accounts for several
aspects of the relationship between consciousness and the brain. Integrated information …

The role of variability in motor learning

AK Dhawale, MA Smith… - Annual review of …, 2017 - annualreviews.org
Trial-to-trial variability in the execution of movements and motor skills is ubiquitous and
widely considered to be the unwanted consequence of a noisy nervous system. However …

Robust neuronal dynamics in premotor cortex during motor planning

N Li, K Daie, K Svoboda, S Druckmann - Nature, 2016 - nature.com
Neural activity maintains representations that bridge past and future events, often over many
seconds. Network models can produce persistent and ram** activity, but the positive …

Efficient codes and balanced networks

S Denève, CK Machens - Nature neuroscience, 2016 - nature.com
Recent years have seen a growing interest in inhibitory interneurons and their circuits. A
striking property of cortical inhibition is how tightly it balances excitation. Inhibitory currents …

Consciousness is supported by near-critical slow cortical electrodynamics

D Toker, I Pappas, JD Lendner, J Frohlich… - Proceedings of the …, 2022 - pnas.org
Mounting evidence suggests that during conscious states, the electrodynamics of the cortex
are poised near a critical point or phase transition and that this near-critical behavior …

Simultaneous all-optical manipulation and recording of neural circuit activity with cellular resolution in vivo

AM Packer, LE Russell, HWP Dalgleish, M Häusser - Nature methods, 2015 - nature.com
We describe an all-optical strategy for simultaneously manipulating and recording the
activity of multiple neurons with cellular resolution in vivo. We performed simultaneous two …

Single-neuron perturbations reveal feature-specific competition in V1

SN Chettih, CD Harvey - Nature, 2019 - nature.com
The computations performed by local neural populations, such as a cortical layer, are
typically inferred from anatomical connectivity and observations of neural activity. Here we …