Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
The role of bile salts in digestion
Bile salts (BS) are bio-surfactants present in the gastrointestinal tract (GIT) that play a crucial
role in the digestion and absorption of nutrients. The importance of BS for controlled release …
role in the digestion and absorption of nutrients. The importance of BS for controlled release …
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
Intestinal health relies on the immunosuppressive activity of CD4+ regulatory T (Treg) cells.
Expression of the transcription factor Foxp3 defines this lineage, and can be induced …
Expression of the transcription factor Foxp3 defines this lineage, and can be induced …
[HTML][HTML] Layer-by-layer encapsulation of probiotics for delivery to the microbiome
Recent discoveries in biology and microbiology have highlighted the importance of the
gastrointestinal (GI) microbiome in regulating human health and disease.[1] Thus, the …
gastrointestinal (GI) microbiome in regulating human health and disease.[1] Thus, the …
Solubilization of membranes by detergents
30 membrane structure and function it is usually necessary to dissociate the membrane into
its components. The techniques for extraction and analysis of the membrane lipids are well …
its components. The techniques for extraction and analysis of the membrane lipids are well …
The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug
S Klein - The AAPS journal, 2010 - Springer
Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …
behavior of drug formulations. To reduce the size and number of human studies required to …
[HTML][HTML] Bile acid diarrhea: prevalence, pathogenesis, and therapy
M Camilleri - Gut and liver, 2015 - ncbi.nlm.nih.gov
Bile acid diarrhea (BAD) is usually seen in patients with ileal Crohn's disease or ileal
resection. However, 25% to 50% of patients with functional diarrhea or diarrhea …
resection. However, 25% to 50% of patients with functional diarrhea or diarrhea …
Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades
AF Hofmann, LR Hagey - Journal of lipid research, 2014 - ASBMB
During the last 80 years there have been extraordinary advances in our knowledge of the
chemistry and biology of bile acids. We present here a brief history of the major …
chemistry and biology of bile acids. We present here a brief history of the major …
Bacteria-induced colloidal encapsulation for probiotic oral delivery
C Zhang, X Gao, X Ren, T Xu, Q Peng, Y Zhang… - ACS …, 2023 - ACS Publications
Probiotic oral delivery has crucial implications in biomedical engineering, but its oral
bioavailability remains unsatisfactory because of the limited survival and colonization of …
bioavailability remains unsatisfactory because of the limited survival and colonization of …
[HTML][HTML] Food ingredients that inhibit cholesterol absorption
ED Jesch, TP Carr - Preventive nutrition and food science, 2017 - ncbi.nlm.nih.gov
Cholesterol is a vital component of the human body. It stabilizes cell membranes and is the
precursor of bile acids, vitamin D and steroid hormones. However, cholesterol accumulation …
precursor of bile acids, vitamin D and steroid hormones. However, cholesterol accumulation …