Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

Balanced organogenesis requires the orchestration of multiple cellular interactions to create
the collective cell behaviours that progressively shape develo** tissues. It is currently …

Living cells are viscoelastic materials, dominated by an elastic response on timescales
longer than a millisecond. On shorter timescales, the dynamics of individual cytoskeleton …

In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …

Abstract Force-displacement (FZ) curves are the most commonly used Atomic Force
Microscopy (AFM) mode to measure the local, nanoscale elastic properties of soft materials …

Mammalian cells frequently migrate through tight spaces during normal embryogenesis,
wound healing, diapedesis, or in pathological situations such as metastasis. Nuclear size …

In this review, we compare the reported values of Young's modulus (YM) obtained from
indentation and tensile deformations of soft biological tissues. When the method of …

We present a procedure that allows a reliable determination of the elastic (Young's) modulus
of soft samples, including living cells, by atomic force microscopy (AFM). The standardized …