Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …
a transdiagnostic process that can account for behavioral deficits and influence underlying …
Synapse-to-nucleus signaling in neurodegenerative and neuropsychiatric disorders
Synapse-to-nucleus signaling is critical for converting signals received at synapses into
transcriptional programs essential for cognition, memory, and emotion. This neuronal …
transcriptional programs essential for cognition, memory, and emotion. This neuronal …
CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
Activation of voltage-gated calcium channels at presynaptic terminals leads to local
increases in calcium and the fusion of synaptic vesicles containing neurotransmitter …
increases in calcium and the fusion of synaptic vesicles containing neurotransmitter …
Sex‐dependent effects of Cacna1c haploinsufficiency on juvenile social play behavior and pro‐social 50‐kHz ultrasonic communication in rats
As cross‐disorder risk gene, CACNA1C is implicated in the etiology of all major
neuropsychiatric disorders characterized by deficits in social behavior and communication …
neuropsychiatric disorders characterized by deficits in social behavior and communication …
Dosage-sensitive genes in autism spectrum disorders: From neurobiology to therapy
Autism spectrum disorders (ASDs) are a group of heterogenous neurodevelopmental
disorders affecting 1 in 59 children. Syndromic ASDs are commonly associated with …
disorders affecting 1 in 59 children. Syndromic ASDs are commonly associated with …
Voltage-induced calcium release in Caenorhabditis elegans body muscles
L Gao, E Ardiel, S Nurrish… - Proceedings of the …, 2024 - National Acad Sciences
Type 1 voltage-activated calcium channels (CaV1) in the plasma membrane trigger calcium
release from the sarcoplasmic reticulum (SR) by two mechanisms. In voltage-induced …
release from the sarcoplasmic reticulum (SR) by two mechanisms. In voltage-induced …
Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains
Mutations altering the scaffolding protein Shank are linked to several psychiatric disorders,
and to synaptic and behavioral defects in mice. Among its many binding partners, Shank …
and to synaptic and behavioral defects in mice. Among its many binding partners, Shank …
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro
AN Harracksingh, A Singh, TD Mayorova, B Bejoy… - Scientific Reports, 2024 - nature.com
PDZ domain mediated interactions with voltage-gated calcium (CaV) channel C-termini play
important roles in localizing membrane Ca2+ signaling. The first such interaction was …
important roles in localizing membrane Ca2+ signaling. The first such interaction was …
The production of a synthetic chemodisruptive peptide in planta precludes Meloidogyne incognita multiplication in Solanum melongena
Root-knot nematodes (RKNs) impose a severe constraint on eggplant productivity and
sustainable options to minimize nematode populations below the economic threshold level …
sustainable options to minimize nematode populations below the economic threshold level …
Clustering of CaV1.3 L‐type calcium channels by Shank3
Clustering of L‐type voltage‐gated Ca2+ channels (LTCCs) in the plasma membrane is
increasingly implicated in creating highly localized Ca2+ signaling nanodomains. For …
increasingly implicated in creating highly localized Ca2+ signaling nanodomains. For …