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[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …
[HTML][HTML] The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies
T Zhong, W Zhang, H Guo, X Pan, X Chen, Q He… - … Pharmaceutica Sinica B, 2022 - Elsevier
Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …
permeable channels, and those relevant transmembrane and intracellular TRP channels …
Circadian clock and hypoxia
F Sartor, B Ferrero-Bordera, J Haspel… - Circulation …, 2024 - ahajournals.org
The timing of life on Earth is remarkable: between individuals of the same species, a highly
similar temporal pattern is observed, with shared periods of activity and inactivity each day …
similar temporal pattern is observed, with shared periods of activity and inactivity each day …
Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice
Respiratory chemoreceptor activity encoding arterial Pco2 and Po2 is a critical determinant
of ventilation. Currently, the relative importance of several putative chemoreceptor …
of ventilation. Currently, the relative importance of several putative chemoreceptor …
Implantable application of polymer‐based biosensors
Implantable sensors offer a great opportunity to extract physiological information from inside
the body by real‐time monitoring. With the demand for personal healthcare and point‐of …
the body by real‐time monitoring. With the demand for personal healthcare and point‐of …
Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia
As blood oxygenation decreases (hypoxemia), mammals mount cardiorespiratory
responses, increasing oxygen to vital organs. The carotid bodies are the primary oxygen …
responses, increasing oxygen to vital organs. The carotid bodies are the primary oxygen …
The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production
M Kakae, H Nakajima, S Tobori, A Kawashita… - Science …, 2023 - science.org
Vascular cognitive impairment (VCI) refers to cognitive alterations caused by vascular
disease, which is associated with various types of dementia. Because chronic cerebral …
disease, which is associated with various types of dementia. Because chronic cerebral …
Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders
A Nakao, Y Matsunaga, K Hayashida… - Frontiers in Cell and …, 2021 - frontiersin.org
Psychiatric disorders are caused by complex and diverse factors, and numerous
mechanisms have been proposed for the pathogenesis of these disorders. Accumulating …
mechanisms have been proposed for the pathogenesis of these disorders. Accumulating …
Mechanisms underlying the sensation of dyspnea
I Fukushi, M Pokorski, Y Okada - Respiratory Investigation, 2021 - Elsevier
Dyspnea is defined as a subjective experience of breathing discomfort that consists of
qualitatively distinct sensations that vary in intensity. It is a common symptom among …
qualitatively distinct sensations that vary in intensity. It is a common symptom among …
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog
M Dai, X Gui, S Jia, S Lv, H Dou, W Cui - Acta Pharmacologica Sinica, 2023 - nature.com
Abstract Dl-3-n-butylphthalide (NBP) is a small-molecule drug used in the treatment of
ischemic stroke in China, which is proven to ameliorate the symptoms of ischemic stroke and …
ischemic stroke in China, which is proven to ameliorate the symptoms of ischemic stroke and …