[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

[HTML][HTML] The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies

T Zhong, W Zhang, H Guo, X Pan, X Chen, Q He… - … Pharmaceutica Sinica B, 2022 - Elsevier
Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Circadian clock and hypoxia

F Sartor, B Ferrero-Bordera, J Haspel… - Circulation …, 2024 - ahajournals.org
The timing of life on Earth is remarkable: between individuals of the same species, a highly
similar temporal pattern is observed, with shared periods of activity and inactivity each day …

Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice

GMPR Souza, DS Stornetta, Y Shi, E Lim… - Journal of …, 2023 - jneurosci.org
Respiratory chemoreceptor activity encoding arterial Pco2 and Po2 is a critical determinant
of ventilation. Currently, the relative importance of several putative chemoreceptor …

Implantable application of polymer‐based biosensors

X Mei, D Ye, F Zhang, C Di - Journal of Polymer Science, 2022 - Wiley Online Library
Implantable sensors offer a great opportunity to extract physiological information from inside
the body by real‐time monitoring. With the demand for personal healthcare and point‐of …

Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia

NO Barioni, F Derakhshan, L Tenorio Lopes… - Science …, 2022 - science.org
As blood oxygenation decreases (hypoxemia), mammals mount cardiorespiratory
responses, increasing oxygen to vital organs. The carotid bodies are the primary oxygen …

The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production

M Kakae, H Nakajima, S Tobori, A Kawashita… - Science …, 2023 - science.org
Vascular cognitive impairment (VCI) refers to cognitive alterations caused by vascular
disease, which is associated with various types of dementia. Because chronic cerebral …

Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders

A Nakao, Y Matsunaga, K Hayashida… - Frontiers in Cell and …, 2021 - frontiersin.org
Psychiatric disorders are caused by complex and diverse factors, and numerous
mechanisms have been proposed for the pathogenesis of these disorders. Accumulating …

Mechanisms underlying the sensation of dyspnea

I Fukushi, M Pokorski, Y Okada - Respiratory Investigation, 2021 - Elsevier
Dyspnea is defined as a subjective experience of breathing discomfort that consists of
qualitatively distinct sensations that vary in intensity. It is a common symptom among …

Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog

M Dai, X Gui, S Jia, S Lv, H Dou, W Cui - Acta Pharmacologica Sinica, 2023 - nature.com
Abstract Dl-3-n-butylphthalide (NBP) is a small-molecule drug used in the treatment of
ischemic stroke in China, which is proven to ameliorate the symptoms of ischemic stroke and …