Given the progress reported during the past decade, a wide range of chemical modifications
may be incorporated into potential antisense drugs. These modifications may influence all …

The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-)
cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three …

Early growth response factor-1 (Egr-1) binds to the promoters of many genes whose
products influence cell movement and replication in the artery wall. Here we targeted Egr-1 …

The sidewalls of vertically aligned, multiwalled carbon nanotubes were functionalized using
azide photochemistry, and DNA oligonucleotides were synthesized in situ from the reactive …

The finding that RNA can perform enzyme-like functions in cells overturned the view that
biological catalysis is the exclusive realm of protein enzymes. The list of naturally occurring …

The hammerhead ribozyme is a small RNA motif that self cleaves at a specific
phosphodiester bond to produce 2′, 3′ cyclic phosphate and 5′ hydroxyl termini …

A biologic role for the 72-kDa gelatinase A (matrix metalloproteinase 2; MMP-2), beyond
simple extracellular matrix turnover, was evaluated in glomerular mesangial cells. To …

Since the discovery of self-cleavage and ligation activity of the group I intron, the expansion
of research interest in catalytic nucleic acids has provided a valuable nonprotein resource …

Previously, nonenzymatic primer extension reaction of acyclic l-threoninol nucleic acid (La
TNA) was achieved in the presence of N-cyanoimidazole (CNIm) and Mn2+; however, the …