[HTML][HTML] Revisiting retinal degeneration hallmarks: Insights from molecular markers and therapy perspectives

JGS Rosa, GR Disner, FJ Pinto, C Lima… - International Journal of …, 2023 - mdpi.com
Visual impairment and blindness are a growing public health problem as they reduce the life
quality of millions of people. The management and treatment of these diseases represent …

[HTML][HTML] Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs

JL Duncan, A Bowman, A Laster… - … Vision Science & …, 2024 - iovs.arvojournals.org
Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD)
are leading causes of irreversible vision loss and blindness. Although significant progress …

Enhanced mitochondrial biogenesis promotes neuroprotection in human pluripotent stem cell derived retinal ganglion cells

M Surma, K Anbarasu, S Dutta… - Communications …, 2023 - nature.com
Mitochondrial dysfunctions are widely afflicted in central nervous system (CNS) disorders
with minimal understanding on how to improve mitochondrial homeostasis to promote …

Rhodopsin mislocalization drives ciliary dysregulation in a novel autosomal dominant retinitis pigmentosa knock‐in mouse model

S Takita, S Jahan, S S. Imanishi… - The FASEB …, 2024 - Wiley Online Library
Rhodopsin mislocalization encompasses various blind conditions. Rhodopsin
mislocalization is the primary factor leading to rod photoreceptor dysfunction and …