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[HTML][HTML] Methods of inactivation of highly pathogenic viruses for molecular, serology or vaccine development purposes
The handling of highly pathogenic viruses, whether for diagnostic or research purposes,
often requires an inactivation step. This article reviews available inactivation techniques …
often requires an inactivation step. This article reviews available inactivation techniques …
Inactivated virus vaccines from chemistry to prophylaxis: merits, risks and challenges
I Delrue, D Verzele, A Madder… - Expert review of …, 2012 - Taylor & Francis
The aim of this review is to make researchers aware of the benefits of an efficient quality
control system for prediction of a developed vaccine's efficacy. Two major goals should be …
control system for prediction of a developed vaccine's efficacy. Two major goals should be …
HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
Abstract Human immunodeficiency virus 1 (HIV-1) infection is initiated by binding of the viral
envelope glycoprotein (Env) to the cell-surface receptor CD4,,–. Although high-resolution …
envelope glycoprotein (Env) to the cell-surface receptor CD4,,–. Although high-resolution …
N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression
The internal N 6-methyladenosine (m6A) methylation of eukaryotic nuclear RNA controls
post-transcriptional gene expression, which is regulated by methyltransferases (writers) …
post-transcriptional gene expression, which is regulated by methyltransferases (writers) …
Distribution and three-dimensional structure of AIDS virus envelope spikes
Envelope glycoprotein (Env) spikes on AIDS retroviruses initiate infection of host cells and
are therefore targets for vaccine development. Though crystal structures for partial Env …
are therefore targets for vaccine development. Though crystal structures for partial Env …
Molecular architecture of native HIV-1 gp120 trimers
The envelope glycoproteins (Env) of human and simian immunodeficiency viruses (HIV and
SIV, respectively) mediate virus binding to the cell surface receptor CD4 on target cells to …
SIV, respectively) mediate virus binding to the cell surface receptor CD4 on target cells to …
Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing …
Induction of broadly cross-reactive neutralizing antibodies is a high priority for AIDS vaccine
development but one that has proven difficult to be achieved. While most immunogens …
development but one that has proven difficult to be achieved. While most immunogens …
[HTML][HTML] Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice
HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing
antibodies. However, Env structure and organization in its native virion context has eluded …
antibodies. However, Env structure and organization in its native virion context has eluded …
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
SG Hansen, C Vieville, N Whizin, L Coyne-Johnson… - Nature medicine, 2009 - nature.com
The rapid onset of massive, systemic viral replication during primary HIV or simian
immunodeficiency virus (SIV) infection and the immune evasion capabilities of these viruses …
immunodeficiency virus (SIV) infection and the immune evasion capabilities of these viruses …
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions
We used electron tomography to directly visualize trilobed presumptive envelope (env)
glycoprotein structures on the surface of negatively stained HIV type 1 (HIV-1) and simian …
glycoprotein structures on the surface of negatively stained HIV type 1 (HIV-1) and simian …