Chemopreventive properties of 3, 3′-diindolylmethane in breast cancer: evidence from experimental and human studies

CA Thomson, E Ho, MB Strom - Nutrition reviews, 2016 - academic.oup.com
Diet is a modifiable factor associated with the risk of several cancers, with convincing
evidence showing a link between diet and breast cancer. The role of bioactive compounds …

Indole derivatives as anticancer agents for breast cancer therapy: a review

J Singh Sidhu, R Singla, V Jaitak - Anti-Cancer Agents in …, 2016 - ingentaconnect.com
Breast cancer (BC) is the second most common cause of cancer-related deaths in women
throughout the world. Multiple drugs have been approved by US-FDA for breast related …

Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer …

C Qu, W Zhang, G Zheng, Z Zhang, J Yin… - Molecular and cellular …, 2014 - Springer
Breast cancer is the most frequently diagnosed tumor type and the primary leading cause of
cancer deaths in women worldwide and multidrug resistance is the major obstacle for breast …

[HTML][HTML] Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity

S Imran, M Taha, NH Ismail, KM Khan, F Naz… - Molecules, 2014 - mdpi.com
In an effort to develop new antibacterial drugs, some novel bisindolylmethane derivatives
containing Schiff base moieties were prepared and screened for their antibacterial activity …

The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis

M Sarkar, V Khare, KKN Guturi, N Das, MK Ghosh - Oncogene, 2015 - nature.com
Increased abundance of proto-oncogene AKT and reduced expression of tumor suppressor
Forkhead box O3 (FOXO3a), the downstream target of AKT, is frequent in carcinogenesis …

HAUSP, a novel deubiquitinase for Rb–MDM 2 the critical regulator

S Bhattacharya, MK Ghosh - The FEBS journal, 2014 - Wiley Online Library
Tumor suppressor retinoblastoma‐associated protein (Rb) is an important cell cycle
regulator, arresting cells in early G1. It is commonly inactivated in cancers and its level is …

Blockade of GLUT1 by WZB117 resensitizes breast cancer cells to adriamycin

Q Chen, YQ Meng, XF Xu, J Gu - Anti-Cancer Drugs, 2017 - journals.lww.com
The tolerance to adriamycin of cancer as a common and stubborn obstacle occurred during
curing breast cancer patients needs to be overcome. In the present study, we explored …

[HTML][HTML] Wnt/β-catenin signaling and p68 conjointly regulate CHIP in colorectal carcinoma

S Kal, S Chakraborty, S Karmakar, MK Ghosh - Biochimica et Biophysica …, 2022 - Elsevier
Emerging evidences suggest abundant expression of Carboxy terminus of Hsc70 Interacting
Protein or CHIP (alias STIP1 Homology and U–box Containing Protein 1 or STUB1) in …

DEAD-box protein p68 is regulated by β-catenin/transcription factor 4 to maintain a positive feedback loop in control of breast cancer progression

KKN Guturi, M Sarkar, A Bhowmik, N Das… - Breast Cancer …, 2014 - Springer
Introduction Nuclear accumulation of β-catenin is important for cancer development and it is
found to overlap with p68 (DDX5) immunoreactivity in most breast cancers, as indicated by …

Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3, 3'-diindolylmethane nanoparticles through blood brain barrier prevents glioma …

A Bhowmik, S Chakravarti, A Ghosh, R Shaw… - …, 2017 - pmc.ncbi.nlm.nih.gov
Current therapy for Glioblastoma is insufficient because of the presence of blood brain
barrier. It limits the transport of essential drugs to the tumor sites. To overcome this limitation …