[HTML][HTML] Cell-matrix reciprocity in 3D culture models with nonlinear elasticity

K Liu, M Wiendels, H Yuan, C Ruan, PHJ Kouwer - Bioactive Materials, 2022 - Elsevier
Abstract Three-dimensional (3D) matrix models using hydrogels are powerful tools to
understand and predict cell behavior. The interactions between the cell and its matrix …

Structure and applications of PIC-based polymers and hydrogels

K Liu, J Vandaele, H Yuan, KG Blank… - Cell Reports Physical …, 2024 - cell.com
Over the last decade, water-soluble polyisocyanopeptides (PICs) have emerged as a new
class of biomimetic polymers. Analogous to biopolymers, PICs exhibit a semi-flexible nature; …

Crosslinking of fibrous hydrogels

DC Schoenmakers, AE Rowan, PHJ Kouwer - Nature communications, 2018 - nature.com
In contrast to most synthetic hydrogels, biological gels are made of fibrous networks. This
architecture gives rise to unique properties, like low concentration, high porosity gels with a …

Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair

RC op't Veld, OI van den Boomen, DMS Lundvig… - Biomaterials, 2018 - Elsevier
Changing wound dressings inflicts pain and may disrupt wound repair. Novel synthetic
thermosensitive hydrogels based on polyisocyanopeptide (PIC) offer a solution. These gels …

Synthetic extracellular matrices with nonlinear elasticity regulate cellular organization

K Liu, SM Mihaila, A Rowan, E Oosterwijk… - …, 2019 - ACS Publications
One of the promises of synthetic materials in cell culturing is that control over their molecular
structures may ultimately be used to control their biological processes. Synthetic polymer …

Biomimetic networks with enhanced photodynamic antimicrobial activity from conjugated polythiophene/polyisocyanide hybrid hydrogels

H Yuan, Y Zhan, AE Rowan, C **ng… - Angewandte Chemie …, 2020 - Wiley Online Library
Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)‐generation
efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed …

Combining mechanical tuneability with function: biomimetic fibrous hydrogels with nanoparticle crosslinkers

W Chen, PHJ Kouwer - Advanced Functional Materials, 2021 - Wiley Online Library
Fibrous networks of biopolymers possess unique properties: mechanical stability at low
concentrations, an extremely porous architecture, and strong stiffening at small …

Temperature-responsive alkaline aqueous biphasic system for radioactive wastewater treatment

C Liu, J Lan, Q Yan, Z Wang, C Xu, W Shi… - Chinese Chemical …, 2022 - Elsevier
The treatment of anionic 99 TcO 4− in the waste tank with high alkalinity is still very
challenging. In this work, a new temperature-responsive alkaline aqueous biphasic system …

Semiflexible polymer scaffolds: an overview of conjugation strategies

L Gerrits, R Hammink, PHJ Kouwer - Polymer Chemistry, 2021 - pubs.rsc.org
Semiflexible polymers play an important role in nature and possess remarkable properties
that render them efficient scaffolds. While flexible polymers coil up, semiflexible polymers …

Fibrous Hydrogels under Multi‐Axial Deformation: Persistence Length as the Main Determinant of Compression Softening

P de Almeida, PA Janmey… - Advanced Functional …, 2021 - Wiley Online Library
When hydrogels are designed for biological applications, the mechanical properties are
carefully chosen to match their precise application. However, traditional methodologies of …