The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

Human cognitive abilities are generally thought to arise from cortical expansion over the
course of human brain evolution. In addition to increased neuron numbers, this cortical …

The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

We describe convergent evidence from transcriptomics, morphology, and physiology for a
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus …

Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or
hypersynchronous activity. Recent progress in the field has outlined two concepts regarding …

Brain function operates through the coordinated activation of neuronal assemblies. Graph
theory predicts that scale-free topologies, which include “hubs”(superconnected nodes), are …

Synaptic transmission constitutes the primary mode of communication between neurons. It is
extensively studied in rodent but not human neocortex. We characterized synaptic …

Generating a comprehensive description of cortical networks requires a large-scale,
systematic approach. To that end, we have begun a pipeline project using multipatch …