The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

We present a physics-based machine learning approach to predict in vitro transcription
factor binding affinities from structural and mechanical DNA properties directly derived from …

Linalool and ionone are two important aromatic components in sweet osmanthus petals, and
the regulatory mechanisms that produce these two components remain unclear. In this …

Germ cells are unique in engendering totipotency, yet the mechanisms underlying this
capacity remain elusive. Here, we perform comprehensive and in‐depth nucleome analysis …

Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure
and function, reflecting changes in the composition of diverse effector proteins over time …

Abstract Background Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain
tumor. Despite extensive tumor resection followed by radio-and chemotherapy, life …

Single nucleotide polymorphisms (SNPs) are the most common type of variation in the
human genome. The vast majority of SNPs identified in the human genome do not have any …

Distinct nucleosome (Nuc) architectures decode key regulatory information related to
various cellular processes. However, how fragile nucleosomes (FNs) and resistant …

Perennial trees develop and coordinate endogenous response signaling pathways,
including their crosstalk and convergence, to cope with various environmental stresses …

Pseudogenes have been considered as non-functional genes. However, peptides and long
non-coding RNAs produced by pseudogenes are expressed in different tumors. Moreover …