The essential elements of Alzheimer's disease
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
Amyloid-β and tau complexity—towards improved biomarkers and targeted therapies
Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
Neurodegenerative diseases and oxidative stress
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's
disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially …
disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially …
The neurobiology of zinc in health and disease
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …
Truncated and modified amyloid-beta species
Alzheimer's disease pathology is closely connected to the processing of the amyloid
precursor protein (APP) resulting in the formation of a variety of amyloid-beta (Aβ) peptides …
precursor protein (APP) resulting in the formation of a variety of amyloid-beta (Aβ) peptides …
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
Background Alzheimer disease (AD) may be caused by the toxic accumulation of β-amyloid
(Aβ). Objective To test this theory, we developed a clinical intervention using clioquinol, a …
(Aβ). Objective To test this theory, we developed a clinical intervention using clioquinol, a …
Amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review
D Allan Butterfield - Free radical research, 2002 - Taylor & Francis
Oxidative stress, manifested by protein oxidation, lipid peroxidation, DNA oxidation and 3-
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …
[HTML][HTML] The redox chemistry of the Alzheimer's disease amyloid β peptide
There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …
Copper in the brain and Alzheimer's disease
Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The brain
is particularly vulnerable to oxidative damage induced by unregulated redox-active metals …
is particularly vulnerable to oxidative damage induced by unregulated redox-active metals …