Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions
A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease
Oxidative stress has long been implicated in Parkinson's disease (PD) pathogenesis,
although the sources and regulation of reactive oxygen species (ROS) production are poorly …
although the sources and regulation of reactive oxygen species (ROS) production are poorly …
Targeting mitophagy in neurodegenerative diseases
O Antico, PW Thompson, NT Hertz… - Nature Reviews Drug …, 2025 - nature.com
Mitochondrial dysfunction is a hallmark of idiopathic neurodegenerative diseases, including
Parkinson disease, amyotrophic lateral sclerosis, Alzheimer disease and Huntington …
Parkinson disease, amyotrophic lateral sclerosis, Alzheimer disease and Huntington …
Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current Insights and Future Directions
Y Gu, X Zhao, N Zhang, Y Yang, Y Yi, Q Shao… - Ageing Research …, 2024 - Elsevier
Neurodegenerative diseases, as common diseases in the elderly, tend to become younger
due to environmental changes, social development and other factors. They are mainly …
due to environmental changes, social development and other factors. They are mainly …