Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

A major challenge in the post-genome era will be determination of the functions of the
encoded protein sequences. Since it is generally assumed that the function of a protein is …

Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable …

Abstract “Natively unfolded” proteins occupy a unique niche within the protein kingdom in
that they lack ordered structure under conditions of neutral pH in vitro. Analysis of amino …

The experimental material accumulated in the literature on the conformational behavior of
intrinsically unstructured (natively unfolded) proteins was analyzed. Results of this analysis …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

▪ Abstract Membrane fusion involves the merger of two phospholipid bilayers in an aqueous
environment. In artificial lipid bilayers, fusion proceeds by means of defined transition states …

Syntaxin 1a and neuronal Sec1 (nSec1) form an evolutionarily conserved heterodimer that
is essential for vesicle trafficking and membrane fusion. The crystal structure of the nSec1 …

Syntaxin 1, an essential protein in synaptic membrane fusion, contains a helical
autonomously folded N‐terminal domain, a C‐terminal SNARE motif and a transmembrane …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …