Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment
Y Sun, L Feng, L Liang, GN Stacey… - Stem Cells …, 2021 - academic.oup.com
Brain degeneration and damage is difficult to cure due to the limited endogenous repair
capability of the central nervous system. Furthermore, drug development for treatment of …
capability of the central nervous system. Furthermore, drug development for treatment of …
Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1. 2-L1342P …
With the wide adoption of genomic sequencing in children having seizures, an increasing
number of SCN2A genetic variants have been revealed as genetic causes of epilepsy …
number of SCN2A genetic variants have been revealed as genetic causes of epilepsy …
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons
S Bracha, HJ Johnson, NA Pranckevicius, F Catto… - Nature …, 2024 - nature.com
Delivering macromolecules across biological barriers such as the blood–brain barrier limits
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …
EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons
SS Parker, KT Ly, AD Grant, J Sweetland… - Journal of Cell …, 2023 - rupress.org
Dendritic spines are the postsynaptic compartment of a neuronal synapse and are critical for
synaptic connectivity and plasticity. A developmental precursor to dendritic spines, dendritic …
synaptic connectivity and plasticity. A developmental precursor to dendritic spines, dendritic …
IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii
S Chandrasekaran, JA Kochanowsky, EF Merritt… - Nature …, 2022 - nature.com
Dogma holds that Toxoplasma gondii persists in neurons because neurons cannot clear
intracellular parasites, even with IFN-γ stimulation. As several recent studies questioned this …
intracellular parasites, even with IFN-γ stimulation. As several recent studies questioned this …
ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons
JA Kochanowsky, S Chandrasekaran… - PLoS …, 2023 - journals.plos.org
Toxoplasma gondii establishes a long-lived latent infection in the central nervous system
(CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life …
(CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life …
Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments
Skeletal muscle stem cells (MuSCs) are essential for efficacious muscle repair, making
MuSCs promising therapeutic targets for tissue engineering and regenerative medicine …
MuSCs promising therapeutic targets for tissue engineering and regenerative medicine …
Differentiation of human iPS cells into sensory neurons exhibits developmental stage-specific cryopreservation challenges
R Li, P Walsh, V Truong, A Petersen… - Frontiers in Cell and …, 2021 - frontiersin.org
Differentiation of human induced pluripotent stem cells (hiPSCs) generates cell phenotypes
valuable for cell therapy and personalized medicine. Successful translation of these hiPSC …
valuable for cell therapy and personalized medicine. Successful translation of these hiPSC …
N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex
S Moazzeni, K Kyker-Snowman, RI Cohen, H Wang… - Scientific Reports, 2025 - nature.com
Tension-adhesion interplay is a crucial mechanism in multicellular organisms that
determines the tension differential among internal and external interfaces, which in turn …
determines the tension differential among internal and external interfaces, which in turn …
Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma
K Onuma, Y Sato, H Okuyama… - The Journal of …, 2021 - Wiley Online Library
Micropapillary carcinoma (MPC) is a morphologically distinctive form of carcinoma,
composed of small nests of cancer cells surrounded by lacunar spaces. Invasive MPC is …
composed of small nests of cancer cells surrounded by lacunar spaces. Invasive MPC is …