Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment

Y Sun, L Feng, L Liang, GN Stacey… - Stem Cells …, 2021 - academic.oup.com
Brain degeneration and damage is difficult to cure due to the limited endogenous repair
capability of the central nervous system. Furthermore, drug development for treatment of …

Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1. 2-L1342P …

Z Que, MI Olivero-Acosta, J Zhang, M Eaton… - Journal of …, 2021 - Soc Neuroscience
With the wide adoption of genomic sequencing in children having seizures, an increasing
number of SCN2A genetic variants have been revealed as genetic causes of epilepsy …

Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons

S Bracha, HJ Johnson, NA Pranckevicius, F Catto… - Nature …, 2024 - nature.com
Delivering macromolecules across biological barriers such as the blood–brain barrier limits
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …

EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons

SS Parker, KT Ly, AD Grant, J Sweetland… - Journal of Cell …, 2023 - rupress.org
Dendritic spines are the postsynaptic compartment of a neuronal synapse and are critical for
synaptic connectivity and plasticity. A developmental precursor to dendritic spines, dendritic …

IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii

S Chandrasekaran, JA Kochanowsky, EF Merritt… - Nature …, 2022 - nature.com
Dogma holds that Toxoplasma gondii persists in neurons because neurons cannot clear
intracellular parasites, even with IFN-γ stimulation. As several recent studies questioned this …

ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons

JA Kochanowsky, S Chandrasekaran… - PLoS …, 2023 - journals.plos.org
Toxoplasma gondii establishes a long-lived latent infection in the central nervous system
(CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life …

Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments

CM Madl, IA Flaig, CA Holbrook, YX Wang, HM Blau - Biomaterials, 2021 - Elsevier
Skeletal muscle stem cells (MuSCs) are essential for efficacious muscle repair, making
MuSCs promising therapeutic targets for tissue engineering and regenerative medicine …

Differentiation of human iPS cells into sensory neurons exhibits developmental stage-specific cryopreservation challenges

R Li, P Walsh, V Truong, A Petersen… - Frontiers in Cell and …, 2021 - frontiersin.org
Differentiation of human induced pluripotent stem cells (hiPSCs) generates cell phenotypes
valuable for cell therapy and personalized medicine. Successful translation of these hiPSC …

N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex

S Moazzeni, K Kyker-Snowman, RI Cohen, H Wang… - Scientific Reports, 2025 - nature.com
Tension-adhesion interplay is a crucial mechanism in multicellular organisms that
determines the tension differential among internal and external interfaces, which in turn …

Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma

K Onuma, Y Sato, H Okuyama… - The Journal of …, 2021 - Wiley Online Library
Micropapillary carcinoma (MPC) is a morphologically distinctive form of carcinoma,
composed of small nests of cancer cells surrounded by lacunar spaces. Invasive MPC is …