A major challenge for immunologists has been the development of vaccines designed to
emphasize cellular immune responses. One particularly promising approach is the prime …

Abstract The adenovirus type 5 (Ad5)-based vaccine developed by Merck failed to either
prevent HIV-1 infection or suppress viral load in subsequently infected subjects in the STEP …

The rapid onset of massive, systemic viral replication during primary HIV or simian
immunodeficiency virus (SIV) infection and the immune evasion capabilities of these viruses …

The mechanisms linking human immunodeficiency virus replication to the progressive
immunodeficiency of acquired immune deficiency syndrome are controversial, particularly …

A prophylactic vaccine for HIV-1 is badly needed. Despite 20 years of effort, it is still a long
way off. However, considerable progress has been made in understanding the problem. The …

Vaccinia viruses engineered to express foreign genes are powerful vectors for production of
recombinant proteins. Originating from highly efficacious vaccines securing world-wide …

The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5)
vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in …

Abstract The International AIDS Vaccine Initiative has established a consortium to elucidate
mechanisms of protection conferred by live attenuated simian immunodeficiency virus …

Here we report the results of an investigation into the possibility that one mechanism
responsible for the establishment of persistent human immunodeficiency virus infection is an …

Twenty years after the discovery of HIV, there is still no vaccine. This year, an envelope
vaccine aimed at stimulating neutralizing antibodies was unable to protect against infection …