Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …

Engineered human cardiac tissues have been utilized for various biomedical applications,
including drug testing, disease modeling, and regenerative medicine. However, the …

Engineering cardiac tissues and organ models remains a great challenge due to the
hierarchical structure of the native myocardium. The need of integrating blood vessels brings …

The development of increasingly biomimetic human tissue analogs has been a long-
standing goal in two important biomedical applications: drug discovery and regenerative …

We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …

From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

Rationale: More than 25 million individuals have heart failure worldwide, with≈ 4000
patients currently awaiting heart transplantation in the United States. Donor organ shortage …

About 3,000 individuals in the United States are awaiting a donor heart; worldwide, 22
million individuals are living with heart failure. A bioartificial heart is a theoretical alternative …

We demonstrate here a cardiac tissue-engineering strategy addressing multicellular
organization, integration into host myocardium, and directional cues to reconstruct the …