Epilepsy is one of the most common serious brain conditions, affecting over 70 million
people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and …

The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Considering the lack of a comprehensive, multi-faceted overview of the ketogenic diet (KD)
in relation to health issues, we compiled the evidence related to the use of the ketogenic diet …

Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with
associated neuropsychiatric and cognitive comorbidities and increased mortality. Although …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …