The emerging picture of taste coding at the periphery is one of elegant simplicity. Contrary to
what was generally believed, it is now clear that distinct cell types expressing unique …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Humans perceive thousands of compounds as bitter. In sharp contrast, only∼ 25 taste 2
receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how …

Relaxation of selective strength, manifested as a reduction in the efficiency or intensity of
natural selection, can drive evolutionary innovation and presage lineage extinction or loss of …

One key to animal survival is the detection and avoidance of potentially harmful compounds
by their bitter taste. Variable numbers of taste 2 receptor genes expressed in the gustatory …

Mammalian sweet taste is primarily mediated by the type 1 taste receptor Tas1r2/Tas1r3,
whereas Tas1r1/Tas1r3 act as the principal umami taste receptor. Bitter taste is mediated by …

Scope To avoid ingestion of potentially harmful substances, humans are equipped with
about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit …

The molecular machinery for chemosensory transduction in taste buds has received
considerable attention within the last decade. Consequently, we now know a great deal …

One of the unique insights provided by the growing number of fully sequenced genomes is
the pervasiveness of gene duplication and gene loss. Indeed, several metrics now suggest …

Type 2 diabetes (T2D) is a fast-increasing health problem globally, and it results from insulin
resistance and pancreatic β-cell dysfunction. The gastrointestinal (GI) tract is recognized as …