Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …

Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …

Approximately 10% of antimicrobials used by humans in low-and middle-income countries
are estimated to be substandard or falsified. In addition to their negative impact on morbidity …

Abstract Treatment of advanced cancers has benefited from new agents that supplement or
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …

Spatial heterogeneity in antibiotic concentrations is thought to accelerate the evolution of
antibiotic resistance, but current theory and experiments have overlooked the effect of cell …

Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

Brain metastases (BM) occur frequently in many cancers, particularly non–small cell lung
cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with …

Infections with rapidly evolving pathogens are often treated using combinations of drugs with
different mechanisms of action. One of the major goal of combination therapy is to reduce …