[HTML][HTML] Mechanisms of insulin action and insulin resistance
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …
[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus
MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
The role of fatty acids in insulin resistance
B Sears, M Perry - Lipids in health and disease, 2015 - Springer
Insulin resistance is a multi-faceted disruption of the communication between insulin and the
interior of a target cell. The underlying cause of insulin resistance appears to be …
interior of a target cell. The underlying cause of insulin resistance appears to be …
Adipose tissue and adipocytes support tumorigenesis and metastasis
Adipose tissue influences tumor development in two major ways. First, obese individuals
have a higher risk of develo** certain cancers (endometrial, esophageal, and renal cell …
have a higher risk of develo** certain cancers (endometrial, esophageal, and renal cell …
Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
Relationships between rodent white adipose fat pads and human white adipose fat depots
The objective of this review was to compare and contrast the physiological and metabolic
profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat …
profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat …
Changes in plasma free fatty acids associated with type-2 diabetes
Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid
(FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms …
(FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms …
The regulation of fat metabolism during aerobic exercise
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …
remarkable element in understanding if and how physical activity affects the health of both …