Lipid metabolism and lipid signals in aging and longevity
Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …
of genetic pathways have been discovered to regulate lifespan in model organisms …
The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
CircRNA accumulation in the aging mouse brain
Circular RNAs (circRNAs) are a newly appreciated class of RNAs expressed across diverse
phyla. These enigmatic transcripts are most commonly generated by back-splicing events …
phyla. These enigmatic transcripts are most commonly generated by back-splicing events …
Upper thermal limits in terrestrial ectotherms: how constrained are they?
Terrestrial ectotherms are likely to face increased periods of heat stress as mean
temperatures and temperature variability increase over the next few decades. Here, we …
temperatures and temperature variability increase over the next few decades. Here, we …
Advances in understanding of the role of lipid metabolism in aging
During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
Motivation: Numerous microarray studies of aging have been conducted, yet given the noisy
nature of gene expression changes with age, elucidating the transcriptional features of …
nature of gene expression changes with age, elucidating the transcriptional features of …
Pillar [6] arene/paraquat molecular recognition in water: high binding strength, pH-responsiveness, and application in controllable self-assembly, controlled release …
The complexation between a water-soluble pillar [6] arene (WP6) and paraquat (G1) in
water was investigated. They could form a stable 1: 1 [2] pseudorotaxane with an extremely …
water was investigated. They could form a stable 1: 1 [2] pseudorotaxane with an extremely …
Adipose tissue coregulates cognitive function
Obesity is associated with cognitive decline. Recent observations in mice propose an
adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in …
adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in …
Single‐cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions
Stromal–epithelial interactions are critical to the morphogenesis, differentiation, and
homeostasis of the prostate, but the molecular identity and anatomy of discrete stromal cell …
homeostasis of the prostate, but the molecular identity and anatomy of discrete stromal cell …
Apolipoprotein D in oxidative stress and inflammation
G Fyfe-Desmarais, F Desmarais, É Rassart, C Mounier - Antioxidants, 2023 - mdpi.com
Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene is
upregulated in a number of pathologies, including Alzheimer's disease, Parkinson's disease …
upregulated in a number of pathologies, including Alzheimer's disease, Parkinson's disease …