Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 …

Tubulin and microtubules are subject to a remarkable number of post-translational
modifications. Understanding the roles these modifications play in determining the functions …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Alzheimer's disease (AD) is a heterogeneous disease with complex clinicopathological
characteristics. To date, the role of m6A RNA methylation in monocyte-derived macrophages …

Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known
posttranslational modification in the microtubule lumen. It marks stable microtubules and is …

Tubulin undergoes several highly conserved posttranslational modifications (PTMs)
including acetylation, detyrosination, glutamylation, and glycylation. These PTMs …

Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …