B cell depletion therapies in autoimmune disease: advances and mechanistic insights
DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
Memory B cells
T Inoue, T Kurosaki - Nature Reviews Immunology, 2024 - nature.com
Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …
concept that memory B cells play a critical role in protection against repeated infections …
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
B Isho, KT Abe, M Zuo, AJ Jamal, B Rathod… - Science …, 2020 - science.org
While the antibody response to SARS-CoV-2 has been extensively studied in blood,
relatively little is known about the antibody response in saliva and its relationship to systemic …
relatively little is known about the antibody response in saliva and its relationship to systemic …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL
In diffuse large B cell lymphoma (DLBCL), tumors belonging to the ABC but not GCB gene
expression subgroup rely upon chronic active B cell receptor signaling for viability, a …
expression subgroup rely upon chronic active B cell receptor signaling for viability, a …
The expansion of human T-bethighCD21low B cells is T cell dependent
B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …
activation of the adaptive immune system in certain infections and autoimmune disorders …
S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunit
P Nguyen-Contant, AK Embong, P Kanagaiah… - MBio, 2020 - Am Soc Microbiol
The high susceptibility of humans to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection, the cause of coronavirus disease 2019 (COVID-19), reflects the …
(SARS-CoV-2) infection, the cause of coronavirus disease 2019 (COVID-19), reflects the …
Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice
Age-associated B cells (ABCs) are formed under inflammatory conditions and are
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …