Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic …

The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine
metabolic communication is not described. We found that EC-specific loss of the glycolytic …

Vascular malformations are thought to be monogenic disorders that result in dysregulated
growth of blood vessels. In the brain, cerebral cavernous malformations (CCMs) arise owing …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Endothelial sprouting and proliferation are tightly coordinated processes mediating the
formation of new blood vessels during physiological and pathological angiogenesis …

Endothelial cells (ECs) are plastic cells that can switch between growth states with different
bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues …

Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …

The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis,
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …

Rationale: Endothelial cells (ECs) are highly glycolytic and generate the majority of their
energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to …