Focusing on an important biomedical implication of allostery–design of allosteric drugs, we
describe characteristics of allosteric sites, effectors, and their modes of actions …

The rationale for replacing the old binary of structure–function with the trinity of structure,
disorder, and function has gained considerable ground in recent years. A continuum model …

Since nucleic acids and proteins of unicellular prokaryotes are directly exposed to extreme
environmental conditions, it is possible to explore the genomic-proteomic compositional …

While the accelerating quest for precision medicine requires new individually targeting and
selective drugs, and the ability to work with so-called undruggable targets, the realm of …

While the pervasiveness of allostery in proteins is commonly accepted, we further show the
generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel …

Protein biosensors play an increasingly important role as reporters for research and clinical
applications. Here we present an approach for the construction of fully integrated but …

While the therapeutic potential of allosteric drugs is increasingly realized, the discovery of
effectors is largely incidental. The rational design of allosteric effectors requires new state-of …

Intrinsic disorder accounts for the flexibility of protein loops, molecular building blocks that
are largely responsible for the processes and molecular functions of the living world. While …

AlloMAPS 2 is an update of the Allosteric Mutation Analysis and Polymorphism of Signalling
database, which contains data on allosteric communication obtained for predicted structures …

Cell division control protein 42 homolog (Cdc42) protein, a Ras superfamily GTPase,
regulates cellular activities, including cancer progression. Using all-atom molecular …