Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …

Inflammation is the first response of the body's immune system to injury, infection and stress.
Chronic inflammation has close relationship with many diseases, such as arthritis …

Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

The intestinal mucosal barrier is composed of epithelial cells that are protected by an
overlying host-secreted mucous layer and functions as the first line of defence against …

Commensal bacteria are critically involved in the establishment of tolerance against
inflammatory challenges, the molecular mechanisms of which are just being uncovered. All …

Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause …