Artemisinin is a promising and a potent antimalarial drug, which meets the dual challenge
posed by drug-resistant parasites and rapid progression of malarial illness. This review …

A discrepancy seems to prevail with regard to the toxicity and safety of the artemisinin family
of antimalarials. While these compounds have been found to be virtually void of any serious …

In two steps from dihydroartemisinin, a small array of 16 semisynthetic C-10 pyrrole Mannich
artemisinin derivatives (7a− p) have been prepared in moderate to excellent yield. In vitro …

The neurotoxicity of-arteether (AE) is related to drug accumulation in blood due to slow and
prolonged absorption from the intramuscular injection sites. In this efficacy and toxicity study …

Artemisinin and its derivatives were discovered to be highly effective antimalarial drugs,
which combine potent, rapid antimalarial activity with a wide therapeutic index and an …

Pharmacokinetic data were obtained to evaluate the therapeutic potential of Artemotil (-
arteether) in 56 Thai patients with severe Plasmodium falciparum malaria. Intramuscular …

Multiple doses of arteether (ARTE) at 25 mg/kg cause CNS and anorectic toxicities in rats.
The same dose of ARTE was used to study the toxicokinetics (TK) after multiple injections …

One hundred thirty-eight adult patients with acute Plasmodium falciparum malaria were
randomized to receive either ß-arteether or α/ß-arteether. The drugs were administered in …

Chloroquine resistance in P. falciparum was first detected in 1973 in Assam. The problem of
drug resistance intensified in that area and gradually spread to the rest of the country …

This article discusses the burden of malaria in India and consequences of the emergence of
antimalarial resistance. The use of drug combinations containing artemisinin compounds, ie …