Eosinophilia and eosinophil activation are recurrent features in various reactive states and
certain hematologic malignancies. In patients with hypereosinophilia (HE), HE‐induced …

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

Autoinflammatory disease can result from monogenic errors of immunity. We describe a
patient with early-onset multi-organ immune dysregulation resulting from a mosaic, gain-of …

Background Inborn errors of immunity (IEI) with dysregulated JAK/STAT signaling present
with variable manifestations of immune dysregulation and infections. Hematopoietic stem …

The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …

Signal transducer and activator of transcription (STAT)-6 is a transcription factor central to
pro-allergic immune responses, although the function of human STAT6 at the whole …

Primary immunodeficiencies (PIDs) comprise a diverse group of over 400 genetic disorders
that result in clinically apparent immune dysfunction. Although PIDs are classically …

Hyper-activated STAT5B variants are high value oncology targets for pharmacologic
intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes …