Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol
use disorders are phenotypically complex and heritable. The heritability of alcohol use …

Imaging genetics offers the possibility of detecting associations between genotype and brain
structure as well as function, with effect sizes potentially exceeding correlations between …

Excessive alcohol consumption is one of the main causes of death and disability worldwide.
Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of …

Mental disorders represent an increasing personal and financial burden and yet treatment
development has stagnated in recent decades. Current disease classifications do not reflect …

Substance use disorders (SUD) are chronic relapsing disorders governed by continually
shifting cycles of positive drug reward experiences and drug withdrawal-induced negative …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Tolerance occurs when, following an initial experience with a substance, more of the
substance is required subsequently to induce identical behavioral effects. Tolerance is not …

Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …