Histone variants—ancient wrap artists of the epigenome
Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …
Nucleosome remodeling and epigenetics
Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …
and developmental cues through the action of a family of so-called “nucleosome …
Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements
Nucleosome-to-protamine exchange during mammalian spermiogenesis is essential for
compaction and protection of paternal DNA. It is interesting that, depending on the species …
compaction and protection of paternal DNA. It is interesting that, depending on the species …
From meiosis to postmeiotic events: the secrets of histone disappearance
One of the most obscure phenomena in modern biology is the near genome‐wide
displacement of histones that occurs during the postmeiotic phases of spermatogenesis in …
displacement of histones that occurs during the postmeiotic phases of spermatogenesis in …
Histone variant H2A. Bbd is associated with active transcription and mRNA processing in human cells
Variation in chromatin composition and organization often reflects differences in genome
function. Histone variants, for example, replace canonical histones to contribute to regulation …
function. Histone variants, for example, replace canonical histones to contribute to regulation …
Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated …
Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and
display some unusual genomic and epigenetic properties that provide valuable insight into …
display some unusual genomic and epigenetic properties that provide valuable insight into …
[HTML][HTML] Nucleosome adaptability conferred by sequence and structural variations in histone H2A–H2B dimers
Highlights•Substitution of canonical histones with variants is crucial for nucleosome
function.•Variant H2A–H2B dimers are recognized and substituted as a distinct …
function.•Variant H2A–H2B dimers are recognized and substituted as a distinct …
Nuclear envelope, chromatin organizers, histones, and DNA: The many achilles heels exploited across cancers
AK Balaji, S Saha, S Deshpande, D Poola… - Frontiers in Cell and …, 2022 - frontiersin.org
In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and
histones that organize and regulate gene expression. The dysregulation of chromatin …
histones that organize and regulate gene expression. The dysregulation of chromatin …
Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals
Eukaryotic genomes must accomplish both compact packaging for genome stability and
inheritance, as well as accessibility for gene expression. They do so using post-translational …
inheritance, as well as accessibility for gene expression. They do so using post-translational …
Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin
Abstract Human histone H2A. B (formerly H2A. Bbd), a non-allelic H2A variant, exchanges
rapidly as compared to canonical H2A and preferentially associates with actively transcribed …
rapidly as compared to canonical H2A and preferentially associates with actively transcribed …