Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Map** tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor
cells can fundamentally improve our understanding of tumor biology, facilitates the …

Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and
survival while subject to changes in environmental cues. Thus, a vital component of a cancer …

Rationale: Malignant ascites in peritoneal metastases is a lipid-enriched microenvironment
and is frequently involved in the poor prognosis of epithelial ovarian cancer (EOC) …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die,
partly because they experience oxidative stress. Metastasizing cancer cells migrate through …

Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

Lipid metabolic reprogramming is an established trait of cancer metabolism that guides
response and resistance to antitumoral therapies. Enhanced lipogenesis, increased lipid …