Structures and coordination chemistry of transporters involved in manganese and iron homeostasis

S Ray, R Gaudet - Biochemical Society Transactions, 2023 - portlandpress.com
A repertoire of transporters plays a crucial role in maintaining homeostasis of biologically
essential transition metals, manganese, and iron, thus ensuring cell viability. Elucidating the …

TerC proteins function during protein secretion to metalate exoenzymes

B He, AJ Sachla, JD Helmann - Nature Communications, 2023 - nature.com
Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported
metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC …

The trans-Golgi-localized protein BICAT3 regulates manganese allocation and matrix polysaccharide biosynthesis

J He, B Yang, G Hause, N Rössner… - Plant …, 2022 - academic.oup.com
Abstract Manganese (Mn2+) is essential for a diversity of processes, including
photosynthetic water splitting and the transfer of glycosyl moieties. Various Golgi-localized …

Emergence of Orchestrated and Dynamic Metabolism of Saccharomyces cerevisiae

V Nguyen, Y Li, T Lu - ACS synthetic biology, 2024 - ACS Publications
Microbial metabolism is a fundamental cellular process that involves many biochemical
events and is distinguished by its emergent properties. While the molecular details of …

Golgi‐localized calcium/manganese transporters FgGdt1 and FgPmr1 regulate fungal development and virulence by maintaining Ca2+ and Mn2+ homeostasis in …

C Wu, Z Guo, M Zhang, H Chen, M Peng… - Environmental …, 2022 - Wiley Online Library
Calcium and manganese transporters play important roles in regulating Ca2+ and Mn2+
homeostasis in cells, which is necessary for the normal physiological activities of …

The YBR056W-A and Its Ortholog YDR034W-B of S. cerevisiae Belonging to CYSTM Family Participate in Manganese Stress Overcoming

A Zvonarev, L Ledova, L Ryazanova, A Valiakhmetov… - Genes, 2023 - mdpi.com
The CYSTM (cysteine-rich transmembrane module) protein family comprises small
molecular cysteine-rich tail-anchored membrane proteins found in many eukaryotes. The …

Allosteric links between the hydrophilic N‐terminus and transmembrane core of human Na+/H+ antiporter NHA2

D Velázquez, V Průša, G Masrati, E Yariv… - Protein …, 2022 - Wiley Online Library
The human Na+/H+ antiporter NHA2 (SLC9B2) transports Na+ or Li+ across the plasma
membrane in exchange for protons, and is implicated in various pathologies. It is a 537 …

The Effect of Phycocyanin Isolated from Arthrospira platensis on the Oxidative Stress in Yeasts

AG Rogov, YE Sergeeva, DV Sukhinov… - Nanobiotechnology …, 2023 - Springer
C-phycocyanin, being a component of the photosynthetic apparatus of cyanobacteria, is an
effective antioxidant and anti-inflammatory agent and is often used in medical studies. The …

Transcriptome Analysis and SNP Identification Reveal That Heterologous Overexpression of Two Uncharacterized Genes Enhances the Tolerance of Magnaporthe …

Y Wang, L Liu, X Pu, C Ma, H Qu, M Wei… - Microbiology …, 2022 - Am Soc Microbiol
Manganese is a crucial trace element that constitutes the cofactors of many enzymes.
However, excessive Mn2+ can be toxic for both prokaryotes and eukaryotes. The …

Metal homeostasis as critical determinant for cellular fitness

J Diessl - 2021 - diva-portal.org
Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and
manganese regulate a plethora of cellular processes ranging from signaling and oxidative …