1, 3, 4-Thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry

Y Hu, CY Li, XM Wang, YH Yang, HL Zhu - Chemical reviews, 2014 - ACS Publications
Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Natural and synthetic coumarins as antileishmanial agents: A review

GA Gonçalves, AR Spillere, GM das Neves… - European Journal of …, 2020 - Elsevier
The neglected tropical disease leishmaniasis is still a major public health problem that
affects millions of people worldwide. Related to poor-living conditions, this vector-borne …

Secondary metabolites: Secondary metabolic products consisting of C and H; C, H, and O; N, S, and P elements; and O/N heterocycles

ANM Alamgir, ANM Alamgir - Therapeutic use of medicinal plants and their …, 2018 - Springer
Terpenes and terpenoids, steroids and sterols, volatile oils, miscellaneous isoprenoids,
phenols and phenyl propanoids, alkaloids, glycosides, bitter principles, resins, saponins …

Synthesis and anti-leishmanial activity of 5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazol-2-amines containing N-[(1-benzyl-1H-1, 2, 3-triazol-4-yl) methyl] moieties

A Tahghighi, S Razmi, M Mahdavi, P Foroumadi… - European journal of …, 2012 - Elsevier
A novel series of 5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazol-2-amines were synthesized by
introducing N-[(1-benzyl-1H-1, 2, 3-triazol-4-yl) methyl] moiety as a new functionality on the …

Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery

LSC Bernardes, CL Zani… - Current medicinal …, 2013 - ingentaconnect.com
According to World Health Organization (WHO), trypanosomiasis and leishmaniasis are the
most challenging among the neglected tropical diseases. Comparative studies between …

Antiprotozoal agents: How have they changed over a decade?

VS Fernandes, R da Rosa, LA Zimmermann… - Archiv der …, 2022 - Wiley Online Library
Neglected tropical diseases are a diverse group of communicable diseases that are
endemic in low‐or low‐to‐middle‐income countries located in tropical and subtropical …

Synthesis and antileishmanial evaluation of 1-aryl-4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives

MS dos Santos, MLV Oliveira, AMR Bernardino… - Bioorganic & medicinal …, 2011 - Elsevier
A series of 1-aryl-4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (4a–g) and 5-amino-1-aryl-
4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (5a–g) were synthesized and evaluated in …

Intestinal targeting of drugs: rational design approaches and challenges

KJ Filipski, MV Varma, AF El-Kattan… - Current Topics in …, 2013 - ingentaconnect.com
Targeting drugs to the gastrointestinal tract has been and continues to be an active area of
research. Guttargeting is an effective means of increasing the local concentration of active …

Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives

VS Gontijo, WAS Judice, B Codonho, IO Pereira… - European journal of …, 2012 - Elsevier
The natural biflavonoids morelloflavone-4‴-O-β-d-glycosyl (1),(±)-fukugiside (2) and
morelloflavone (3) were isolated from the ethyl acetate extract (EAEE) of dried and …

Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents

ME Caputto, A Ciccarelli, F Frank, AG Moglioni… - European journal of …, 2012 - Elsevier
A series of novel 4-arylthiazolylhydrazones (TZHs) derived from 1-indanones were
synthesized in good yields (66–92%) in a simple procedure using microwave irradiation and …