Age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases
Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …
created a critical need to experimentally validate the disease-associated variants, 90% of …
[HTML][HTML] The retinal pigmentation pathway in human albinism: Not so black and white
R Bakker, EL Wagstaff, CC Kruijt, E Emri… - Progress in retinal and …, 2022 - Elsevier
Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …
[HTML][HTML] Implications of genetic variation in the complement system in age-related macular degeneration
Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …
in the Western world. While AMD is a multifactorial disease, the complement system was …
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function
E Cerniauskas, M Kurzawa-Akanbi, L **e… - Stem cells …, 2020 - academic.oup.com
Age-related macular degeneration (AMD) is a multifactorial disease, which is characterized
by loss of central vision, affecting one in three people by the age of 75. The Y402H …
by loss of central vision, affecting one in three people by the age of 75. The Y402H …
Experimental models in neovascular age related macular degeneration
Neovascular age-related macular degeneration (vAMD), characterized by the neo-
vascularization of the retro-foveolar choroid, leads to blindness within few years. This …
vascularization of the retro-foveolar choroid, leads to blindness within few years. This …
Targeting lipid metabolism for the treatment of age-related macular degeneration: insights from preclinical mouse models
Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …
impairment in the world with limited therapeutic interventions. Histological, biochemical …
[HTML][HTML] Systems genomics in age-related macular degeneration
AI den Hollander, RF Mullins, LD Orozco… - Experimental eye …, 2022 - Elsevier
Genomic studies in age-related macular degeneration (AMD) have identified genetic
variants that account for the majority of AMD risk. An important next step is to understand the …
variants that account for the majority of AMD risk. An important next step is to understand the …
Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology
BA Pfeffer, SJ Fliesler - Experimental eye research, 2022 - pubmed.ncbi.nlm.nih.gov
Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology
Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology Exp …
Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology Exp …
Neuronal cell differentiation of human dental pulp stem cells on synthetic polymeric surfaces coated with ECM proteins
Y Gao, Z Tian, Q Liu, T Wang, LK Ban… - Frontiers in Cell and …, 2022 - frontiersin.org
Stem cells serve as an ideal source of tissue regeneration therapy because of their high
stemness properties and regenerative activities. Mesenchymal stem cells (MSCs) are …
stemness properties and regenerative activities. Mesenchymal stem cells (MSCs) are …