SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …

Candidiasis is a common infection of the skin, oral cavity and esophagus, gastrointestinal
tract, vagina and vascular system of humans. Although most infections occur in patients who …

Organisms in fluctuating environments must constantly adapt their behavior to survive. In
clonal populations, this may be achieved through sensing followed by response or through …

Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla
of life. Accumulating evidence indicates that sirtuins are important regulators of organism life …

Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are
found in organisms from all biological kingdoms. SIR2 itself was originally discovered to …

Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone
deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively …

Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic
individuality, a biological phenomenon that is considered to bolster the fitness of …

The common fungal pathogen, Candida albicans, can grow either as single cells or as
filaments (hyphae), depending on environmental conditions. Several transcriptional …

Awareness of Candida albicans as a major human health threat has risen during recent
years. Although infections by C. albicans can be relatively mild and superficial, systemic …

How eukaryotes specify their replication origins is an important unanswered question. Here,
we analyze the replicative organization of yeast rDNA, which consists of∼ 150 identical …