Acetate revisited: A key biomolecule at the nexus of metabolism, epigenetics and oncogenesis—Part 1: Acetyl-CoA, acetogenesis and acyl-CoA short-chain …

JR Moffett, N Puthillathu, R Vengilote… - Frontiers in …, 2020 - frontiersin.org
Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

G Wang, Y Yu, YZ Wang, JJ Wang… - Journal of cellular …, 2019 - Wiley Online Library
Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

[HTML][HTML] ChatGPT and the rise of generative AI: Threat to academic integrity?

DO Eke - Journal of Responsible Technology, 2023 - Elsevier
The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Short-chain fatty acids as a potential treatment for infections: a closer look at the lungs

MG Machado, V Sencio, F Trottein - Infection and immunity, 2021 - journals.asm.org
Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via
the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a …

Modulation of the tumor microenvironment by microbiota-derived short-chain fatty acids: impact in colorectal cancer therapy

S Gomes, AC Rodrigues, V Pazienza… - International Journal of …, 2023 - mdpi.com
Finding new therapeutic approaches towards colorectal cancer (CRC) is of increased
relevance, as CRC is one of the most common cancers worldwide. CRC standard therapy …

The roles of microbial products in the development of colorectal cancer: a review

Y Fang, C Yan, Q Zhao, J Xu, Z Liu, J Gao, H Zhu… - …, 2021 - Taylor & Francis
ABSTRACT A large number of microbes exist in the gut and they have the ability to process
and utilize ingested food. It has been reported that their products are involved in colorectal …

Nutrient inputs and social metabolic control of T cell fate

ZA Bacigalupa, MD Landis, JC Rathmell - Cell Metabolism, 2024 - cell.com
Cells in multicellular organisms experience diverse neighbors, signals, and evolving
physical environments that drive functional and metabolic demands. To maintain proper …

The multiple facets of acetyl-CoA metabolism: Energetics, biosynthesis, regulation, acylation and inborn errors

Y Wang, H Yang, C Geerts, A Furtos, P Waters… - Molecular Genetics and …, 2023 - Elsevier
Abstract Acetyl-coenzyme A (Ac-CoA) is a core metabolite with essential roles throughout
cell physiology. These functions can be classified into energetics, biosynthesis, regulation …

The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: prevention and therapeutic implications

SD Gomes, CS Oliveira, J Azevedo-Silva… - Current medicinal …, 2020 - benthamdirect.com
Colorectal Cancer (CRC) is a major cause of cancer-related death worldwide. CRC
increased risk has been associated with alterations in the intestinal microbiota, with …

[HTML][HTML] Microbiota-derived short-chain fatty acids: new road in colorectal cancer therapy

S Gomes, F Baltazar, E Silva, A Preto - Pharmaceutics, 2022 - mdpi.com
The colon microbiota is an important player in colorectal cancer (CRC) development, which
is responsible for most of the cancer-related deaths worldwide. During carcinogenesis, the …